Miguel Medina Selected Research

Glycogen Synthase Kinase 3

2/2019	Effects of Thioflavin T and GSK-3 Inhibition on Lifespan and Motility in a Caenorhabditis elegans Model of Tauopathy.
1/2018	Bi-directional genetic modulation of GSK-3β exacerbates hippocampal neuropathology in experimental status epilepticus.
2/2014	A longitudinal FDG-PET study of transgenic mice overexpressing GSK- 3β in the brain.
1/2014	New insights into the role of glycogen synthase kinase-3 in Alzheimer's disease.
5/2013	Understanding the relationship between GSK-3 and Alzheimer's disease: a focus on how GSK-3 can modulate synaptic plasticity processes.
1/2013	Treatment of Alzheimer's disease with the GSK-3 inhibitor tideglusib: a pilot study.
1/2012	Evidence for irreversible inhibition of glycogen synthase kinase-3β by tideglusib.
1/2011	Modulation of GSK-3 as a Therapeutic Strategy on Tau Pathologies.
1/2010	Glycogen synthase kinase-3 (GSK-3) inhibitors for the treatment of Alzheimer's disease.
7/2008	Glycogen synthase kinase-3 (GSK-3) inhibitors reach the clinic.

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Miguel Medina Research Topics

Disease

28	Alzheimer Disease (Alzheimer's Disease) 01/2021 - 09/2003
10	Neurodegenerative Diseases (Neurodegenerative Disease) 03/2020 - 07/2008
9	Tauopathies 03/2020 - 01/2014
6	Dementia (Dementias) 01/2022 - 05/2002
4	Cognitive Dysfunction 01/2021 - 01/2019
3	Nervous System Diseases (Neurological Disorders) 01/2018 - 01/2014
3	Brain Diseases (Brain Disorder) 01/2018 - 08/2008
2	COVID-19 12/2021 - 01/2021
2	Amyloid Plaque 03/2020 - 01/2012
2	Status Epilepticus (Complex Partial Status Epilepticus) 01/2018 - 01/2017
2	Neoplasms (Cancer) 02/2013 - 07/2008
2	Bipolar Disorder (Manic Depressive Psychosis) 01/2011 - 07/2008
2	Inflammation (Inflammations) 01/2010 - 05/2006
1	Coronavirus Infections 01/2021
1	Genetic Risk Score 01/2021
1	Memory Disorders (Memory Loss) 03/2020
1	Brain Injuries (Brain Injury) 01/2018
1	Mental Disorders (Mental Disorder) 01/2018
1	Epilepsy (Aura) 01/2018
1	Disease Progression 01/2018
1	Traumatic Brain Injuries (Traumatic Brain Injury) 01/2017
1	Huntington Disease (Huntington's Disease) 01/2017
1	Craniosynostoses (Craniosynostosis) 09/2016
1	Facial Nerve Injuries 05/2013
1	Thrombosis (Thrombus) 03/2013
1	Mood Disorders (Mood Disorder) 02/2013
1	Reperfusion Injury 01/2013
1	Ischemia 01/2013
1	Necrosis 06/2012
1	Progressive Supranuclear Palsy (Steele Richardson Olszewski Syndrome) 01/2012
1	Schizophrenia (Dementia Praecox) 01/2011
1	Tuberculosis (Tuberculoses) 10/2008
1	Stroke (Strokes) 07/2008
1	Neuroblastoma 09/2007
1	Wounds and Injuries (Trauma) 11/2004
1	Parkinson Disease (Parkinson's Disease) 05/2002

Drug/Important Bio-Agent (IBA)

11	Glycogen Synthase Kinase 3IBA 02/2019 - 09/2007
8	Amyloid (Amyloid Fibrils)IBA 01/2021 - 06/2004
7	Proteins (Proteins, Gene)FDA Link 03/2020 - 09/2003
7	Pharmaceutical PreparationsIBA 01/2019 - 01/2011
5	Glycogen Synthase (Synthase I)IBA 01/2018 - 01/2010
4	Biomarkers (Surrogate Marker)IBA 01/2022 - 01/2017
4	tau Proteins (tau Protein)IBA 03/2020 - 01/2014
4	EnzymesIBA 01/2014 - 07/2006
3	Biological ProductsIBA 01/2022 - 11/2005
3	Apolipoproteins E (ApoE)IBA 12/2021 - 01/2021
3	MicroRNAs (MicroRNA)IBA 11/2019 - 01/2017
3	Microtubule-Associated Proteins (Microtubule-Associated Protein 2)IBA 11/2017 - 01/2014
3	Cholinesterase Inhibitors (Anticholinesterases)IBA 04/2014 - 11/2005
2	Peptides (Polypeptides)IBA 03/2020 - 01/2015
2	Glucose (Dextrose)FDA LinkGeneric 01/2019 - 01/2010
2	N-Methylaspartate (NMDA)IBA 04/2014 - 01/2011
2	tideglusibIBA 01/2013 - 01/2012
1	Eukaryotic Initiation Factor-4EIBA 01/2022
1	Coffee FDA Link 01/2021
1	sharpinIBA 01/2021
1	TeaIBA 01/2021
1	VaccinesIBA 03/2020
1	DNA (Deoxyribonucleic Acid)IBA 03/2020
1	A-Form DNA (A-DNA)IBA 03/2020
1	NeuroglobinIBA 01/2020
1	thioflavin TIBA 02/2019
1	Tetracycline (Achromycin)FDA LinkGeneric 02/2019
1	Bromazepam (Lexotanil)IBA 01/2019
1	PrionsIBA 03/2018
1	Kainic Acid (Kainate)IBA 01/2018
1	RNA (Ribonucleic Acid)IBA 01/2018
1	Protein Isoforms (Isoforms)IBA 01/2018
1	SuspensionsIBA 05/2013
1	AllodermIBA 05/2013
1	Glycogen Synthase KinasesIBA 02/2013
1	Interleukin-1 (Interleukin 1)IBA 06/2012
1	Interleukin-6 (Interleukin 6)IBA 06/2012
1	tau-protein kinaseIBA 01/2010
1	Interleukin-7 (Interleukin 7)IBA 10/2008
1	AntigensIBA 10/2008
1	manzamine AIBA 09/2007
1	AlkaloidsIBA 07/2006
1	manzamine BIBA 07/2006
1	ircinal AIBA 07/2006
1	Dialysis SolutionsIBA 05/2006
1	AcetylcholinesteraseIBA 01/2006
1	CholesterolIBA 12/2004
1	PresenilinsIBA 09/2003
1	AntibodiesIBA 05/2002
1	alpha-SynucleinIBA 05/2002

Therapy/Procedure

4	Therapeutics 04/2018 - 01/2011
1	Home Nursing (Nursing, Home) 01/2021
1	Institutionalization (Institutionalized Persons) 11/2017
1	Distraction Osteogenesis 09/2016
1	Osteotomy 09/2016
1	Injections 05/2013
1	Rhytidoplasty (Facelift) 05/2013
1	Stents 03/2013
1	Vascularized Composite Allotransplantation 01/2013
1	Oral Administration 01/2012
1	Peritoneal Dialysis 05/2006
1	Continuous Ambulatory Peritoneal Dialysis (CAPD) 05/2006
1	Intramedullary Fracture Fixation 11/2004